The model
Email keeps originals. Letterboxx keeps reading copies.
Letterboxx is not a full live mirror of Mail, Gmail, or Outlook. It connects directly to email accounts using IMAP and uses selected mail folders as sources for the newsletters you want to read later. For more context on why that matters, read A Local-First Reading Library for Newsletters.
Short answer: email remains the source of truth, while Letterboxx becomes the newsletter reading app where selected copies can be organized, cleaned up, highlighted, searched, and backed up on your Mac.
After you connect an account or choose a folder, Letterboxx retrieves newsletters from that selected source and continues checking selected folders for new issues. Original messages remain on the mail server unless you explicitly delete them.